Tyler Slaton led off the top of the first inning with a base hit.
For Clemson's 13th-ranked Tigers, it was all downhill from there.
Georgia Southern, the nation's top power-hitting team, feasted on Clemson pitching for a 14-3 victory Tuesday night in the first of two midweek games at Statesboro, Ga.
The Eagles jumped on Tiger starter Zack Erwin for three runs in the bottom of the first, and then, after leaving the bases loaded in the second, scored four in the third - including three on bases-loaded walks by Erwin and reliever Clate Schmidt.
Clemson scratched out a run in the top of the fourth, but the Eagles hit two-run homers in their next two times at bat - one by Kody Adams in the bottom of the fourth and another by Aaron Mizell in the fifth - to push their lead to 11-1. The homer was Mizell's ninth of the season.
The Tigers picked up a run in the sixth on back-to-back doubles by Chris Okey and Steve Wilkerson, but then gave it back in the bottom of the inning after Toney walked GSU's first two batters on nine pitches.
Georgia Southern added a pair of runs in the seventh, and Clemson picked up three in the top of the ninth.
The final innings were notable only for season debuts for Clemson redshirt freshman pitcher Garrett Lovorn and senior infielder/outfielder Shane Kennedy, who came on as a pitch hitter in the seventh and drew a walk and then finished the game at first base.
Kennedy missed the first third of the season while completing his rehab from ACL surgery. He came into the season as the Tigers' top returning hitters.
Georgia Southern finished with 13 hits, while Clemson had 11. The Tigers committed three errors, and the Eagles had none.
Georgia Southern improved its record to 17-4, while Clemson dropped to 12-7.
The teams will play again on Wednesday at 4 p.m., before Clemson returns home to host No. 1 Florida State in a three-game series.