Struggles at the plate caught up with Clemson's 14th-ranked Tigers on Friday, as Wake Forest scored a pair of runs in the bottom of the eighth and eked out a 4-3 victory at Winston-Salem.
The Deacons (13-6, 3-1) were coming off a 2-1 series victory over Georgia Tech, while the Tigers (10-6, 3-1) had opened conference play with a sweep of Virginia Tech.
The one-run victory was the seventh of the season for Demon Deacons.
The Tigers scratched out just four hits for the second straight game, but carried a 3-2 lead into the eighth thanks to a three-run, fourth-inning home run by freshman catcher Chris Okey.
Clemson starter Daniel Gossett, after working out of a bases-loaded jam in the sixth, gave way to Clate Schmidt, who put the Deacons down in order in the seventh, but then ran into trouble when he walked the first two Wake Forest batters in the eighth.
Closer Matt Campbell came on to pitch for the Tigers, but gave up a run-scoring single to Charlie Morgan to tie the score. Ben Breazeale then delivered a ground-rule double to chase home the go-ahead run.
Campbell got out of the inning without further damage, but the Tigers came up short in the ninth.
Tyler Krieger grounded out to second and Garrett Boulware flied out to right field to start the inning, and then Steve Duggar singled to left field. Okey's chance for a second, game-winning homer ended with a strikeout, however.
In anticipation of bad weather on Sunday, the Tigers and Deacons will play a doubleheader on Saturday, beginning at 1 p.m.
Follow Kerry Capps on Twitter @oandwkc