With an eye on the NCAA's official RPI report, which was released for the first time this week, every game is of high importance to Jack Leggett's Tigers.
Clemson, 18-9, currently sits 12th on the RPI list, and ranks third in the ACC behind No. 3 Florida State and No. 6 Virginia.
The Tigers' 13-2 victory over Furman Tuesday night was their third straight midweek victory, after going 2-2 in their first four midweek games.
Clemson faces another midweek opportunity tonight against No. 201 Winthrop, which a year ago handed the Tigers a 3-2 setback at Doug Kingsmore Stadium.
South Carolina tops the NCAA RPI list, and is followed by Houston, FSU, Kentucky, Texas, Virginia, Florida, Vanderbilt, Rice and Mississippi. Louisiana-Lafayette leads the second 10, followed by Clemson, UNLV, West Virginia, Cal Poly, Indiana, Arizona State, Alabama, Washington and Tennessee.
Maryland, at No. 22, ranks fourth among ACC teams, and is followed by Miami (41), UNC (75), Wake Forest (76), Pittsburgh (81), Georgia Tech (83), Virginia Tech (85), NC State (90), Duke (151), Boston College (167) and Notre Dame (233).
Nine ACC teams recorded non-conference victories on Tuesday, while three suffered setbacks.
Boston College (8-18) edged UConn 2-1, Maryland (17-8) topped Virginia Commonwealth 5-2, Virginia (24-4) was a 7-1 winner over Old Dominion, Virginia Tech (13-12-1) defeated James Madison 11-5, and NC State (16-11) defeated Campbell 9-2.
Notre Dame (11-17) was an 11-1 winner over Valparaiso, North Carolina (16-12) topped UNC-Wilmington 9-4, and Florida State (23-5) defeated Florida Gulf Coast 8-3.
Wake Forest's bid to become the ACC's third 20-game winner was foiled by High Point, 5-1. The Deacons (19-11) will try again today against the same team.
West Virginia won its second straight midweek game over Pittsburgh (15-12), while Liberty knocked off Duke (17-13) by a score of 4-3.
ACC Wednesday Schedule
Winthrop at Clemson
UMass at Boston College
Pitt at Youngstown State
George Washington at Virginia
Radford at Virginia Tech
Bethune-Cookman at Miami
Georgia State at Georgia Tech
East Carolina at NC State
High Point at Wake Forest
ACC Weekend Series
NC State at Clemson (Saturday, Sunday, Monday)
UNC at Boston College
Miami at Virginia Tech
Maryland at Wake Forest
Notre Dame at FSU
Duke at Georgia Tech
Follow Kerry Capps on Twitter @oandwkc