Hopkins snared a three-yard touchdown pass in overtime to lift the Houston Texans to a 30-24 come-from-behind victory over Tennessee.
It was his seventh catch of the game, and pushed his game total to 117 yards. He was targeted 13 times, and averaged 16.7 yards per catch. His longest reception went for 28 yards.
''We survived today because of some great heroics and plays by him,'' Texans' coach Gary Kubiak said of Hopkins.
When Hopkins saw the coverage on the game-winning touchdown, he said he couldn't wait for quarterback Matt Schaub to get the snap.
''Anytime I see a one-on-one, that's a wide receiver's dream,'' Hopkins said. ''He (Schaub) put it in the perfect position for me to go up and catch it. We practice that basically every day and practice makes perfect.''
Hopkins set up the winning score when he outdueled Titans defensive back Jason McCourty for a 25-yard reception on third-and-nine from the Tennessee 26 on the first possession of overtime.
Hopkins' performance set a franchise record for yards receiving ever by a Texans rookie, and tied for the second-most receptions by a rookie in franchise history.
The Texans' website noted that Hopkins' closest friends and family were in attendance at Houston's Reliant Stadium to witness first-hand his breakout performance.
“I probably had about 16 people come from South Carolina,” Hopkins said. “There was probably 10 of them who it was their first time flying.”
Ellington - like Hopkins, a rookie playing in his second NFL game - caught a 36-yard touchdown pass for the Arizona Cardinals in their 25-21 victory over the Detroit Lions. Ellington finished the game with two receptions for 42 yards and four carries for 20 yards, including a 16-yard run.
Jaron Brown had one reception for 11 yards for Arizona.
C.J. Spiller bounced back from a sub-par opener and rushed for 103 yards on 16 carries in Buffalo's 24-23 win over the Carolina Panthers. Spiller's longest run went for 46 yards. He also caught four passes for 26 yards.
Marcus Gilchrist made three solo tackles in the San Diego Chargers' 33-30 victory over Philadelphia.
Chris Clemons had four solo tackles and broke up two passes in the Miami Dolphins' 24-20 win over the Indianapolis Colts.
Jacoby Ford had two receptions for 12 yards and one kickoff return for 26 yards in Oakland's 19-9 victory over Jacksonville.
Coty Sensabaugh made two tackles for the Titans against the Texans.
Phillip Merling had a tackle in Washington's 38-20 loss to Green Bay, while Ricky Sapp had one stop in the New York Jets' 13-10 loss to New England.