Every other year, the ACC schedule demands that Florida State's Seminoles trek north, into Clemson's Valley of Death.
After each of their last five visits, the Seminoles have limped home beaten.
As the Tallahassee Democrat pointed out on Sunday, star quarterback Jameis Winston was a seven-year-old the last time FSU emerged from Death Valley with a victory.
That was 12 years ago, in 2001, when a 14th-ranked Seminole team beat the unranked Tigers 41-27.
In 2003, with FSU ranked third and Clemson again unranked, the Tigers thumped the Seminoles 26-10 to give Tommy Bowden his first 'Bowden Bowl' victory.
In 2005, it was all Clemson, as Charlie Whitehurst passed for 269 yard on Senior Day and the unranked Tigers rolled past No. 17 FSU 35-14.
The 2007 game was a nail-biter, with the unranked Tigers jumping on top 24-3 and then holding on to win 24-18 over an FSU team ranked 19th nationally.
In 2009, with both teams unranked, Clemson won handily, 40-24, led by a school-record 312 all-purpose yards performance by C.J. Spiller.
Two years ago, the two teams had fans on the edge of their seats before Dabo Swinney's 21st-ranked Tigers edged the No. 11 Seminoles 35-30. Tajh Boyd passed for 344 yards, including TD passes of 24 and 62 yards to freshman Sammy Watkins.
Before Clemson won in 2003, Florida State had won the first seven games it played on the Tigers' home field.
But many of them didn't come easy.
It took the 'Puntrooskie' for Bobby Bowden's team to escape Death Valley with a 24-21 victory in 1988.
In 1992 - with FSU ranked No. 5 and making its first trip to Clemson as a member of the ACC - Charlie Ward had to lead a last-minute, fourth-quarter touchdown drive to avoid the upset, 24-20.
In 1995, the No. 1 Seminoles won 45-26, but needed a late-game surge to pull away.
In 1997, Peter Warrick had 372 total yards and three touchdowns as the No. 5 Seminoles escaped with a 35-28 win.
And in 1999, an unbeaten, top-ranked FSU team on its way to the national championship trailed 14-3 at halftime before rallying win the first 'Bowden Bowl' 17-14.
As has been the norm throughout the series, this year's fifth-ranked FSU team enters game week as the odds-makers' favorite over the No. 3 Tigers.
History says a Seminole victory won't come easy.