Andre Ellington has found the going tough the past two weeks while running behind a young, patchwork offensive line.
But the Tigers' fifth-year senior continues to lead the ACC in rushing with his 109.3 per-game average.
Closing the gap on Ellington last week was Florida State's Chris Thompson, who is averaging 84.7 yards per game.
While Ellington and Thompson hold the 1-2 spots in rushing, quarterbacks E.J. Manuel of FSU and Tajh Boyd of Clemson enjoy the same two positions in passing efficiency.
Overall, Florida State has the team statistical edge after three games. The Seminoles enter Saturday's game ranked No. 1 nationally in total defense (103.3), rushing defense (33.67), scoring defense (1.0), passing efficiency defense (60.50) and pass defense (69.67 yards per game).
FSU also ranked second in scoring offense (58.67), eighth in the nation in passing efficiency (177.12), 10th in sacks (3.67), 11th in rushing offense (279.0), 12th in tackles for loss (8.67) and total offense (543.67), and 23rd in sacks allowed.
Clemson ranks in the top 25 nationally in total offense (517.33), scoring (39.67), passing (298.0), and passing efficiency defense (104.55), and is 30th in rushing (219.33).
The Tigers lead the ACC in turnover margin (1.50) and interceptions (5).
Individually, DeAndre Hopkins leads the conference in receptions with 8.7 per game and is second in receiving yardage (106.3) to Boston College's Alex Amidon (122.0).
Chandler Catanzaro is second in field goals with 2.0 per game, and is tied for first in accuracy at 100 percent (6-of-6).
Florida State's Rashad Green leads the conference in punt return average at 19.6 and has two returns for touchdowns in three games.
FSU defensive end Bjoem Werner leads the league in both sacks (2.17) and tackles for loss (3.0).